Additionally, research has demonstrated that Shengmai Fangzheng Injection (SFI), a traditional Chinese medicine formulation, can specifically inhibit the AMPK/PI3K/Akt signaling pathway, suppress muscle cell apoptosis, increase mitochondrial membrane potential, and alleviate mitochondrial dysfunction, thereby improving post-chemotherapy fatigue in cancer patients [23]. This evidence concerns the gene AKT1 and cancer.