The genesets corresponding to EMT, KRAS signaling, IL6/STAT/JAK3, IL2/STAT5, IFN Gamma Response, Inflammatory Response, and TNFa via NFkB, were found to be significantly enriched in both analyses, suggesting a potential mediation by the microbiome of the association between OSCC’s and PML’s phenotypes and selected cancer- and immune-related pathways. This evidence concerns the gene NFKB1 and cancer.