As shown in Fig. 2c-f, TSPAN18 depletion decreased STIM1 expression, accompanied by a shortened half-life, however, TSPAN18 overexpression dramatically prolonged the half-life of the STIM1 protein in PCa cells, suggesting TSPAN18 as a positive regulator of STIM1 protein stability. Here, STIM1 is linked to posterior cortical atrophy.