BRCA1 and ovarian carcinoma: For instance, the combination of the pathogenic variants of BRCA1/2 and high levels of two circulating proteins SPARC (Secreted protein acidic and rich in cysteine) and THBS1 (Thrombospondin 1), can be combined to distinguish women with ovarian cancer from those healthy and with wild type BRCA1/2 variants [75].