EGFR and lymphangioma: Although we have previously shown that EGFR-mutated LM patients are likely to gain limited benefits from WBRT [2], the potential role of osimertinib in combinations with other treatment modalities such as WBRT or intrathecal chemotherapy for specific EGFR-mutated patients was yet to be elucidated, i.e., co-existed with brain metastasis [33] or recurrent LM patients.