EGFR and non-small cell lung carcinoma: In this pooled analysis, we included 11 studies consisting of 353 patients, and the pooled results showed that the ORR, DCR, and one-year OS rate of osimertinib for the treatment of EGFR-mutant NSCLC with LM were 42% (95% CI 24% to 59%), 93% (95% CI 88% to 97%), and 59% (95% CI 53% to 65%), respectively.