The phosphatidylinositol-3 kinase (PI3K)/protein kinase B (PKB, AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in the regulation of a variety of cellular activities, such as proliferation, metabolism, apoptosis, and autophagy, and aberrant activation of this pathway occurs in approximately 50% of HCC patients [62]. Here, AKT1 is linked to hepatocellular carcinoma.