ibeA is functional for cell invasion into the host tissues, Hemolysin A (hlyA) creates pores in membranes of host cells (cell lysis), while fimbrilar papC (pyelonephritis associated Pili) gene stimulates the production of cytokines by T lymphocytes and colonization factor in extraintestinal infections [58]. This evidence concerns the gene PCDH8 and pyelonephritis.