The major component of plaques found in the brains of patients with Alzheimer ́s disease (AD) are 40–42 amino acids long amyloid beta (Aβ) peptides derived from the amyloid precursor protein (APP) by enzymatic cleavage, first with β-secretase (BACE1) and then by γ-secretase [1, 2]. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.