In multivariate regression, palpitation symptoms (OR: 2.59(1.35—4.99), p = 0.004), AMA-M2 positivity (OR: 3.80(1.49—9.68), p = 0.005), elevated LDH level (OR: 3.59(1.86—6.92), p < 0.001) and elevated cTnI level (OR: 4.43(2.03—9.65), p < 0.001) were independently predictive for the HFpEF phenotype after adjusting for confounding clinical risk factors including age, BMI, hypertension, diabetes and interstitial lung disease. Here, TNNI3 is linked to diabetes mellitus.