In multivariate regression, palpitation symptoms (OR: 2.59(1.35—4.99), p = 0.004), AMA-M2 positivity (OR: 3.80(1.49—9.68), p = 0.005), elevated LDH level (OR: 3.59(1.86—6.92), p < 0.001) and elevated cTnI level (OR: 4.43(2.03—9.65), p < 0.001) were independently predictive for the HFpEF phenotype after adjusting for confounding clinical risk factors including age, BMI, hypertension, diabetes and interstitial lung disease. This evidence concerns the gene TNNI3 and hypertensive disorder.