This study provided evidence that ERK1/2 signalling pathway participated in systemic administration of ADSCs for Dex-induced muscle atrophied mice, which alleviate muscle wasting including with increased number of type I fibre, stronger muscle strength, faster recovery rate and more anti-fatigue ability, which can further support the development of pharmaceutical intervention for muscle atrophy. The gene discussed is MAPK3; the disease is Atrophy.