Moreover, according to the 2016 and 2021 WHO classification of CNS tumours [46, 47], gliomas have been classified as IDH1 wild-type (GBM), IDH1 mutations with chromosome 1p19q codeletions (LGG), and IDH1 mutations without chromosome 1p19q codeletions (LGG). Here, IDH1 is linked to central nervous system cancer.