In C6 glioma cells, a parallel reduction was observed in gene expression levels of c-MYC and BCL2 after transfection with the miRNAs named vvi-miR396b, ptc-miR396f, and ptc-miR396f, compared to non-targeting controls (Fig. 9c; Additional file 1: Tables S1–S5). This evidence concerns the gene BCL2 and central nervous system cancer.