Supporting evidence reveals that in addition to water and sodium retention, insulin-induced hypoglycemia could trigger widespread abnormal autonomic nervous system activation, systemic inflammation, oxidative stress, and a prothrombotic state, resulting in myocardial ischemia, overexpression of sodium-hydrogen exchangers, and microvasculature disturbance, thereby promoting cardiomyocyte injury and dysfunction [20–22]. Here, INS is linked to myocardial ischemia.