INS and diabetes mellitus: T2DM patients on insulin treatment exhibited more severe impairment in the magnitude of LV global circumferential PS than T2DM patients not taking insulin or patients without T2DM (DM on insulin: -6.1% ± 2.2% vs. DM not on insulin: -7.3% ± 3.2 vs. non-DM: -7.6% ± 3.3%; P = 0.007).