Moreover, although the levels of intestinal tissue CD4+T and serum IL-2, IL-4, and IFN-γ, and serum IgG, IgA, and SIgA in the MC group were lower than those in the NC group, their levels increased after ASP and CIP treatment, indicating that ASP and CIP could strengthen the immunity of calves. This evidence concerns the gene CD4 and hereditary sensory and autonomic neuropathy.