TNF and hereditary sensory and autonomic neuropathy: ASP and CIP significantly increased IgA (Fig. 7A), IgG (Fig. 7B), IL-4 (Fig. 7D), IL-2 (Fig. 7E), and IFN-γ (Fig. 7F), and decreased IL-6 and TNF-α compared with that in MC group (P < 0.05).