We further analyzed the expression of other markers linked to differentiation, such as prolactin, progesterone receptor (PGR), estrogen receptor alpha (ERα) and smooth muscle actin (SMA) [49], and both the healthy tissue-derived organoids and the miR-203-treated tumor organoids exhibited comparable staining for all the molecular markers tested (Fig. 5E and Additional file 1: Fig. S2B). The gene discussed is PGR; the disease is neoplasm.