In-vitro signaling pathway aberrations in SCA include the death of human gastric cancer cells by changes in the Reactive oxygen species/ Jun N-terminal kinase (ROS/JNK) signaling system [21], reduce interleukin-1β-induced inflammation in human chondrocytes by decreasing NF-κB and MAPK activation [22]. Here, NFKB1 is linked to autosomal dominant cerebellar ataxia.