PRTN3 and autoimmune disease: Hyperstimulation is associated with autoimmune disease development since those with severe COVID-19 developed anti-phospholipid and anti-nuclear antibodies, interferon-neutralizing autoantibodies, and antineutrophil cytoplasmic antibodies against myeloperoxidase (MPO/p-ANCA) and proteinase 3 (PRTN3/c-ANCA) [4].