SFRP5 and diabetes mellitus: Correspondingly, enrichment of hub genes in the DisGeNET [55] and OMIM databases specified heart dysfunction and diabetes as pathogenic mechanisms related to the FAM132A, SFRP5, ADIPOQ, TNF, IL-6, C1QTNF1, CAT, SOD1, SOD2, and SOD3 (Fig. 2G and H).