Overall, a biological explanation for the BBS gene differences that we have observed would relate to the fact that the mitotic spindle assembly checkpoint (MSAC) pathway is one of the most deregulated pathways in MPM and thus the microtubular network that is highly associated with the PC is a point of pathophysiological and therapeutic interest in pleural malignancy [28]. Here, BBS2 is linked to pachyonychia congenita.