MTOR and colorectal cancer: The result in Fig. 6B,C, based on KEGG analysis, DEG has biological functions in Protein processing in endothelial reticulum26, Spliceosome27, mTOR signaling pathway28, and colorectal cancer, as well as in proteomic protein catalytic process, autophagy29, regulation of mRNA metabolic process30, ubiquitin − like protein31 and ubiquitin protein32 based on GO analysis.