KIDINS220 and obesity due to melanocortin 4 receptor deficiency: Additionally, rare novel missense and loss-of-function variants in KIDINS220 gene are associated with schizophrenia [24, 25] and, more recently, SINO (spastic paraplegia, intellectual disability, nystagmus, and obesity) syndrome and ventriculomegaly [26–28], altogether identifying KIDINS220 as a multifaceted player with important functions in human disease.