TMEM37 and infection: Under local infection of Agrobacterium, the induced SAR in the WT plant can also be observed in the pr1 expressing native PR1 but not in the pr1 expressing CNYD/CAPE-mutated PR1. Further, the treatment of AtCAPE9 to the local leaves of pr1 directly enables systemic immunity without Agrobacterium infection, which implies AtCAPE9 may directly or indirectly elicit systemic immunity.