TP53 and colorectal carcinoma: As expected, PES-CI reduces the viability of all CRC cells in a dose-dependent manner (Fig. 4a), with the sensitivity of HCT116 p53wt (IC50 = 10.33 μM; 95% CI 4.937–13.18), HCT116 p53−/− (IC50 = 14.96 μM; 95% CI 12.59–17.91), LS174T (IC50 = 8.451 μM; (95% CI 5.201–9.902) and SW480 (IC50 = 15.78 μM; 95% CI 13.93–17.86) to PES-IC depending on the p53wt status.