Although we did not observe complete infertility using Amh-Cre (presumably due to the repopulation of Sertoli cells that escaped Cre-mediated recombination), smaller testis size and abnormal tubule organization of cKO testes (Fig. 1) suggest that PRC1 is critical for physiological functions of Sertoli cells. The gene discussed is AMH; the disease is Infertility.