Research shows that although cancer cells with high expression of Caspase8 die due to apoptosis, the loss of Caspase8 can down-regulate NF- κ B signal transduction, strengthen the stability of RIPK1 to promote the cell to necroptosis, which is of great significance to improve the anti-cancer strategy of ovarian cancer patients with low expression of Caspase8 [83] (Fig. 6). This evidence concerns the gene RIPK1 and cancer.