Interestingly, α-SMA expression was expressed in the muscularis layer of the colons of Apc−/−/Pkd1−/− mice versus Apc−/− mice, and to a greater extent in the Apc−/−/Pkd1−/− lesions, paralleling results in ADPKD. The gene discussed is ACTA1; the disease is autosomal dominant polycystic kidney disease.