APC and neoplasm: Given the distinct biology of MSS tumors, which typically (~80%) originate with APC mutations, and MSI tumors, where APC mutations are less common and other activating mutations are more prevalent [71], it is possible that PKD1 mutation and restriction of TEI is selectively detrimental in the MSS sequence of tumor formation and progression; although additional work is required to determine whether the relationship is causal or correlative.