Overall, GTF2F2-mediated transcription elongation contributes to the upregulation of TMPO-AS1L and the TMPO-AS1L/DDX3X/CSNK2A1 complex further activates Wnt/β-catenin signaling, thereby promoting PCa BM (Fig. 8C). The gene discussed is CSNK2A1; the disease is posterior cortical atrophy.