To determine the clinical impact of the GTF2F2/TMPO-AS1L/β-catenin axis in PCa samples, ISH and IHC assays were employed to examine the levels of GTF2F2, TMPO-AS1L, DDX3X, CSNK2A1, p-DVL2 and β-catenin in serial sections of PCa specimens. This evidence concerns the gene DVL2 and posterior cortical atrophy.