For instance, in hepatocellular carcinoma, lncRNA-MUF promotes EMT via the Wnt signaling pathway [15], and inhibits SMAD family member 4 (SMAD4) protein degradation in colorectal cancer cells, thereby activating the transforming growth factor beta (TGF-β) signaling pathway [16]. This evidence concerns the gene SMAD4 and hepatocellular carcinoma.