Multiple M0-homeostatic microglial transcripts were repressed in C1QC+ macrophages, including CST3, NFKB1, JUN, and EGR1, while the key transcripts of dysfunctional microglia in neurodegenerative diseases, including APOE, TREM2, and LGALS3, were strongly upregulated32 (Fig. 3d). This evidence concerns the gene LGALS3 and neurodegenerative disease.