Slc25a22 knockout (Slc-KO) CT26 tumors showed lower tumor size (Fig. 1f) together with reduced MDSC (P < 0.01) and PMN-MDSC (P < 0.01), while total T cells and CD8+ T cells were increased (P < 0.01) (Fig. 1g). Here, CCL21 is linked to neoplasm.