CRC organoids from APC-KRAS mutant and Apcmin/+KrasG12D/+Slc25a22fl/flVillin-Cre mice with colon-specific Slc25a22 knockout (APC-KRAS-SLC25A22KO) were implanted in immunocompetent mice (Fig. 1d). The gene discussed is KRAS; the disease is colorectal carcinoma.