KRAS and colorectal carcinoma: Our previous work has shown that SLC25A228,9, a member of mitochondrial transporter family (SLC25) that facilitates the transport of glutamate across the inner mitochondrial membrane into the mitochondrial matrix10,11, functions as an oncogenic factor in KRAS mutant CRC by generating metabolites critical for antioxidative defense8 and epigenetic deregulation9.