APC and colorectal carcinoma: CRC organoids from APC-KRAS mutant and Apcmin/+KrasG12D/+Slc25a22fl/flVillin-Cre mice with colon-specific Slc25a22 knockout (APC-KRAS-SLC25A22KO) were implanted in immunocompetent mice (Fig. 1d).