Re-expression of HBO1 wild-type (HBO1-WT) in HBO1 knockout B-ALL cells promoted the expression of β-catenin at mRNA and protein levels, the acetylation of H3K14, H4K8, and H4K12 (Fig. 6B, C), as well as the activation of Wnt/β-catenin signaling pathway (Fig. 6D) compared with the empty vector (EV) group. This evidence concerns the gene KAT7 and acute lymphoblastic leukemia.