Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis revealed that myonectin-dependent gene changes were associated with Pathway in cancer, Proteoglycans in cancer, Focal adhesion, Adipocytokine signaling pathway, AMP-activated protein kinase (AMPK) signaling pathway and Apelin signaling pathway (Fig. 3a). This evidence concerns the gene APLN and cancer.