NFE2L2 and ischemic stroke: Our results clarified that roflumilast ameliorates rotenone-induced neurotoxicity by upsurging striatal Nrf2 expression along with downregulating Keap 1 expression, which is in line with a previous study showing the neuroprotective effect of roflumilast against ischemic stroke-induced neuronal damage via activating Nrf2 (Xu et al. 2021).