PI3K/AKT cascading axis, via its impact on a plethora of proteins, has been established to be one of the most crucial pathways capable of ameliorating neuronal survival, improving neurogenesis, and repressing apoptosis induced by neurotoxins in PD models (Zheng et al. 2021a, b; Khezri and Ghasemnejad-Berenji 2022; Wang et al. 2022). The gene discussed is AKT1; the disease is Parkinson disease.