Interestingly, while being barely detectable in adult healthy mouse heart tissue, Igf2 is reexpressed upon conditions of ischemia and reperfusion, e.g., during myocardial infarction (MI) [260], which is in line with findings in zebrafish, where the ortholog of Igf2 (igf2b) is found to be upregulated during regeneration [125]. This evidence concerns the gene IGF2 and myocardial infarction.