SLC16A1 and cancer: As the core protein of the lactate transmembrane transport channel, MCT1 directly removes intracellular lactate from tumor cells to maintain continuous glycolysis and leads to the accumulation of lactate in the TME.[9] Mounting evidence has implicated MCT1 in a plethora of tumor biological functions, including proliferation, metastasis, angiogenesis, metabolism, and immunosuppression.[10, 11, 12, 13, 14] It has emerged as a potential target for cancer therapy.