To further explore the relationship between SETDB1, MCT1 K473 tri‐methylation, and M2‐like polarization of TAMs in CRC, we conducted IHC assays on a CRC tissue microarray using anti‐SETDB1, anti‐me3 MCT1 K473, and anti‐CD206 antibodies (Figure S7e, Supporting Information). This evidence concerns the gene MRC1 and colorectal carcinoma.