Furthermore, previous research suggests that tumor‐derived lactate can modulate M2‐like macrophage polarization of TAMs, even though lactate is a by‐product of anaerobic glycolysis.[6, 31] Consistently, we constructed MCT1 3′UTR knockdown CT26 cell lines, which were rescued with mus‐MCT1 WT and mus‐MCT1 K467R, homologous to human MCT1 K473, and measured lactate export and glucose uptake ability (Figure S5g, Supporting Information). Here, SLC16A1 is linked to neoplasm.