It has been observed that LDHA can be phosphorylated at tyrosine 10 (Tyr10) by HER2 and Src, leading to an increase in its enzymatic activity and consequently promoting elevated glycolysis and lactate production.[30] Hence, we detected the LDHA and pLDHA(Tyr10) protein level and found that MCT1 K473 methylation deficiency decreased the level of pLDHA(Tyr10) (Figure 5e).These findings demonstrated that MCT1 K473 tri‐methylation enhances lactate export and tumor cell glycolysis. This evidence concerns the gene ERBB2 and neoplasm.