SETDB1 and colorectal carcinoma: Interestingly, we found that inhibiting the expression of SETDB1 could accelerate the autophagic degradation of MCT1 in CRC cells, as indicated by the rescue of MCT1 degradation by the autophagic‐sequestration inhibitor 3‐methyladenine (3‐MA) or the lysosomal‐acidification inhibitor chloroquine (CQ), but not the proteasome inhibitor MG132 (Figure 2c).