SLC16A1 and colorectal carcinoma: Eukaryotic cells utilize the ubiquitin‐proteasome system and the autophagy‐lysosomal pathway as the two primary pathways for protein degradation.[26, 27] To determine which degradation pathway of MCT1 is predominantly repressed by SETDB1, we treated CRC cells with inhibitors of proteasome or autophagy degradation pathways to detect the degradation of MCT1 under Mithramycin A treatment.