SLC16A1 and colorectal carcinoma: Lactate plays a critical role in tumor progression as it is involved in the maintenance of continuous aerobic glycolysis and regulating immune cells' function in TME, leading to immune escape and M2‐like macrophage polarization.[6, 37, 38, 39, 40] Our study revealed that MCT1 methylation increases the protein stability of MCT1, promoting lactate export in CRC.