For another, chemotherapy with chemotherapeutics (e.g., doxorubicin [DOX], gemcitabine, oxaliplatin, and cyclophosphamide) is capable of triggering immune activation by inducing immunogenic cell death (ICD), activating antigen‐presenting cells, and improving T‐cell infiltration.[7, 8] Unfortunately, chemotherapeutics were found to induce tumor immunosuppression by activating the overexpression of immunosuppression‐related genes such as PD‐L1.[9, 10] Therefore, combination therapy of immune checkpoint blockade and immune activation promotion represents an advanced form of immunotherapy. This evidence concerns the gene CD274 and neoplasm.