Overexpression or mutation of EGFR frequently occurs in human GBM.[8, 9] To examine whether EGFR activation regulates CD47 expression, we treated a panel of human GBM cells, including U251, U87/EGFR, T98G, LN18, and GSC7‐11 cells, A549 lung cancer cell, SW480 colorectal cancer cell (Figure 2A), and mouse glioma cells, including GL261 and CT‐2A, (Figure S2A, Supporting Information) with EGF. Here, CD47 is linked to central nervous system cancer.