CD47 expression can be regulated at the transcriptional level by multiple transcription factors, including signal transducer and activator of transcription 3 (STAT3),[4] β‐catenin–transcription Factor 4 (TCF4),[5] hypoxia‐inducible factor 1 (HIF‐1),[6] and c‐Myc.[7] However, whether CD47 expression is regulated at the posttranslational level, especially in response to tumor‐frequently occurred receptor tyrosine kinases (RTKs) lesions, thereby contributing to tumor immune evasion remains unclear. This evidence concerns the gene MYC and neoplasm.