Integrin‐associated protein (IAP or CD47), a glycosylated five‐transmembrane protein, is frequently overexpressed in hematologic and solid tumors, allowing tumor cells to evade innate immune surveillance.[2] CD47 binds to and activates signal regulatory protein α (SIRPα), an inhibitory protein expressed on the surface of myeloid cells including all types of macrophages. The gene discussed is SIRPA; the disease is neoplasm.