Increasingly, studies in patients with RCC have considered the inclusion of markers of malnutrition (ie, albumin) or inflammation (ie, modified Glasgow Prognostic Score) with sarcopenia measurements to improve prognostication and capture more RCC-specific outcomes, such as RFS.10,32,45,51 By including features that also reflect malnutrition and/or a patient’s inflammatory state, it is possible that sarcopenia secondary to cancer cachexia and tumor aggressiveness may be better captured,52 leading to the improved prediction of RCC-specific outcomes. This evidence concerns the gene ALB and malnutrition.