BRCA1 and glioblastoma: Meanwhile, the knockdown of DARS1-AS1/YBX1 increased the total γ-H2AX level and reduced the expression of FOXM1, RAD51, and BRCA1, the established regulators of HR-mediated DSB repair (43–46), at the RNA and protein level in GBM cells/GSCs (Fig. 8, A to H, and fig.