DARS1 and glioblastoma: Therefore, we hypothesize that the DARS1-AS1/YBX1 axis may promote the HR-mediated repair of DSBs caused by endogenous stress (e.g., replication stress) or exogenous ionizing radiation, and depleting DARS1-AS1 or YBX1 may lead to an increase of DSB level in GBM cells/GSCs.