YBX1 has been suggested to play diverse roles in posttranscriptional regulation, including regulating splicing (31, 32), RNA stability (33, 34), and translation (35, 36), and has been shown to be involved in complex diseases such as cancer (34, 35) and neurological disease [e.g., Rett syndrome (37)]. This evidence concerns the gene YBX1 and nervous system disorder.