ATRX and neuroblastoma: The most common ATRX aberration in neuroblastoma is a MED of exon 2–10 [8] and therefore we visualized all the overlapping significantly changed genes sets with the same Normalised Enrichment Score (NES) directionality (i.e.–or +) between GI-ME-NΔ2–10, NB139Δ2–10, PDΔATRX and iTHERΔ2–10 in bubble plots (Fig 4A).