CTCF and cancer: While some signatures were consistently depleted at CTCF biding sites across the majority of cancer types when compared to simulated data (SBS1, SBS9, SBS10a/b, SBS15, SBS37, SBS84, and SBS85), others were commonly enriched (SBS3, SBS5, SBS7a/b/d, SBS12, SBS17a/b, SBS18, SBS22, and SBS40; DBS1; ID5, ID6, ID8, and ID9; Figure 4A).