Different types of periodicities of mutation rates around the nucleosome structure were observed for signatures associated with tobacco smoking (SBS4 and ID3), UV light (SBS7a/b/c/d), POLE deficiency (SBS10a), aristolochic acid (SBS22), and reactive oxygen species (SBS18, SBS36, and SBS38; Figures 3E and S3). This evidence concerns the gene POLE and hyperinsulinemic hypoglycemia, familial, 4.