The top 10 hub gene include STAT3, ITGB1, FLG, IVL, DDX58, SPRR1B, IFIH1, DSG1, COL17A1, and ITGA6. IL-13/ IL-4 signaling is now considered to be the essential core of the pathogenesis of AD [16, 32]. This evidence concerns the gene COL17A1 and Alzheimer disease.