Lesional AD skin exhibits aberrant expression patterns of proinflammatory factors associated with keratinocytes and T cells, particularly high expression of interleukin 4 (IL-4), interleukin 13 (IL-13), interleukin 4 receptor (IL-4R), interleukin 33 (IL-33), and thymic stromal lymphopoietin (TSLP) [10]. This evidence concerns the gene IL4 and Alzheimer disease.