Consistent with our proposal, paeonol was reported to alleviate C. albicans-associated colitis induced by DSS in mice through suppressing dectin-1/NF-κB signaling in combination with TLR2 and TLR4 (Ge et al. 2021), while the antifungal drug fluconazole treatment could rescue the ulcerative colitis symptoms in mice (Leonardi et al. 2018). This evidence concerns the gene TLR4 and ulcerative colitis.