RRAGA and cancer: The result of CNV loss frequency displayed that ubiquitination-related regulators had higher frequencies of loss mutations in KICH, OV, UCS, ACC, READ, and SARC, while ubiquitin-conjugating enzyme E2G1 (UBE2G1), UBB, peroxisomal E3 ubiquitin ligase peroxin 14 (PEX14), SNF2 histone linker PHD RING helicase (SHPRH), RING finger 152 (RNF152), and Ras-related GTP-binding A (RRAGA) had higher frequencies of loss mutations across various cancer types (Fig. 1B).