Although CXCR 1/2 are potential receptors for CXCL2, CXCL2-CXCR1 is more likely a molecular docking site because CXCL 2 expression was significantly correlated with CXCR1 in three renal cancer datasets (KIRC, P < 0.001; ICGC, P < 0.05; CM, P < 0.001), not significantly correlated with CXCR2 in the KIRC and ICGC datasets. This evidence concerns the gene CXCL2 and renal carcinoma.