Furthermore, we identified three pairs of interactions between CXCL genes and the specific immune cells in renal clear cell carcinoma samples: CXCL13-CD8+ exhausted T cells, CXCL 9/10-M1, and CXCL 1/2/3/8-neutrophil polarization for cancer. Here, CXCL13 is linked to clear cell renal carcinoma.