ADCYAP1 and migraine disorder: A preclinical study demonstrated that PACAP-induced hypersensitivity in a mouse model of migraine-like pain is independent of CGRP.26 However, it is important to interpret these findings cautiously as CGRP receptor antagonism was still able to inhibit pain induced by cilostazol in the same mouse model.27 This suggests that the translatability of the model may have limitations.