HMOX1 is a key survival molecule controlled by NRF2 and involved in the progression of tumors in many cancers66, 67 We showed that the levels of HMOX1 and some other known targets of NRF2 are upregulated in our TAZ knockout MM model and negatively correlated with TAZ (Figure 4D,E). This evidence concerns the gene HMOX1 and Miyoshi myopathy.