Current research on specific protein markers for neurodegenerative diseases has evaluated 30 highly specific proteins associated with the brain as candidate biomarkers for the diagnosis of AD, Among these proteins, CNTN2 may also be indicators of disease progression, showing weak to moderate correlation with cognitive tests, which contain the CNTN2 protein of our interest (Begcevic et al., 2018). This evidence concerns the gene CNTN2 and neurodegenerative disease.