It has been demonstrated that this model, despite reproducing hypertension with low peripheral RAS activity and low circulating AngII levels (Gavras et al., 1975), results in an elevation of RAS cerebral activity (Grobe et al., 2010), neuroimmune axis recruitment (Perrotta et al., 2018), and cerebral damage (Rodrigues and Granger, 2012). The gene discussed is AGT; the disease is hypertensive disorder.