Several findings suggest that the action of AngII on cognitive impairment may be independent from BP levels (Faraco et al., 2016b; Kerkhofs et al., 2020), and thus treating hypertension with the sole aim of lowering the BP levels and mechanical stress to cerebral vasculature may be an inadequate solution for hypertension-induced cognitive impairment. This evidence concerns the gene AGT and Hypertension.