FLG and asthma: As regards the phenotypes of asthma, existing evidence revealed that childhood-onset asthma was highly associated with at least two independent loci, 17q12-21 and filaggrin (FLG) locus; and a relative moderate association was also found between adult-onset asthma, moderate-severe asthma and genes, which are largely a subset of those associated with childhood-onset asthma (8).