IL6 and breast cancer: As observed for M-CSF macrophages, ChemR23 activation by the agonist antibody significantly reduced IL-10, IP-10 and IL-6 secretion, and significantly induced TNFα and IL-1RA secretion while not affecting IL-12p70 in both BC (Figures 5A, S10A) and MPM TAM-like (Figure 5B, S10B).