Moreover, the tumor microenvironment could drive angiogenesis by modulating macrophage activity, thus to address the possibility of the αChemR23 antibody modulation on this function in macrophages, we studied the expression of two well-known genes involved in angiogenesis and vessel remodeling, VEGFA and MMP9 (Figure S11A, B). The gene discussed is MMP9; the disease is neoplasm.