To closer mimic clinic situation for most patients with BC, tumor resection 13 days after tumor cell injection was performed in mice treated with anti-ChemR23 mAb 7-8 days after tumor implantation and 5-6 days before tumor resection (corresponding to the peak of metastatic risk), in order to reprogram ChemR23 expressing cells before the tumor resection and to evaluate the subsequent effect on long term metastatic development. This evidence concerns the gene CMKLR1 and breast cancer.